Immune Response, Toll Like Receptors (TLR) Pathway - IMGENEX

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Toll Like Receptors: The GateKeepers of Innate Immunity

Innate immunity as the first line of defense
The innate immune system is an ancient host defense mechanism found in almost every multicellular organism from plants to humans. In invertebrates it is the sole mechanism of defense against pathogens but in higher vertebrates constitutes the first line of defense. The role of the innate immune system is not an insignificant one; not only must it discriminate between self and non-self as well as distinguish between pathogenic and non-pathogenic microbes, it also plays an important role in triggering and optimizing the adaptive immune response. This remarkable system allows an immediate non-specific response against microorganisms whereas the adaptive immunity mounts a specific response against the invading pathogen during the late phase of the infection.

Category:

Science & Technology

Tags:

• Immune response
• TLR
• Toll Like Receptors
• immunology
• Antibodies
• antibody
• Toll-like Receptor
• medical
• animation
• Response
• Immune
• pathogen
• antigen
• cell
• cellular
• Medicine
• Cell (biology)
• Health
• blood
• Leukocytes
• protein
• macrophage
• proteins

[jennyEvansmd]

Oh Wow!!! Its so nicely represented. Amazing animation and concept. Waiting for more videos like this...

[kandrew5v5]

@jennyEvansmd Thanks for the comments, we are working on 2 additional videos that expand on this presentation. The new videos should fill in some of the gaps ins the sequence that is currently shown.

[dmbball15]

Great video! Thanks!

[kandrew5v5]

@dmbball15 more videos coming! part 2 and 3

[gerbilinatube]

....I thought B7 linked with CD28...

not CD80...are they the same thing? am i in the right church??

[kandrew5v5]

@gerbilinatube i will have to check into this....

[knucklescapricorn31]

Oh my gosh, this is great! Why the hell does this vid only have around 2000 views while other sh!t ones have like over 100,000???

[mozarliszt]

Very good video, so comprehensive！I love it.

[czgoldbe]

@kandrew5v5 They are. Many immune system molecules have a common designation as well as a "cluster of differentiation" designation.

[MsTrance1]

omfg playing deep house during this im LOOOLING

Ps. Dr Philpot sent me here

[HaoSci]

Although I very much appreciate your effort into this, I don't like the molecules to be more like human. Although I would like the text to be bigger (so I can see it clearly), and also hope that the the text to stay with the whatever it labels. Thanks very much.

[karleffertz]

Great video!! when are 2 and 3 coming out??

[2StepMurder]

That was so cool!!

And scientific :D

[capriccioso35]

@gerbilinatube CD 80 is another name for B7 and yes it links with CD28 as a costimulator for T cell ( in this case, CD4 , helper T cells) activation

[YvanRKO]

gotta love it! my favorite is MHC class II... xD

[thewikileaksfan]

Troll like receptor 

[jennyEvansmd]

Cells of the innate immune system effectively prevent free growth of bacteria within the body; however, many pathogens have evolved mechanisms allowing them to evade the innate immune system