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http://moviesget.com The characters of the series include a group of surgical interns and the various physicians who serve as mentors to the interns in their professional and personal lives. The show's producers used a "blind-casting" technique, resulting in a racially diverse cast. All roles for Grey's Anatomy are cast without the characters' races being pre-specified, in keeping with creator Shonda Rhimes's vision of diversity.[5] The five characters who serve as the series' focal point are Meredith Grey (Ellen Pompeo), Alex Karev (Justin Chambers), George O'Malley (T. R. Knight), Izzie Stevens (Katherine Heigl) and Cristina Yang (Sandra Oh). They begin the series as interns at Seattle Grace Hospital, progressing to residency after their first year in the surgical program. They are initially mentored by Miranda Bailey (Chandra Wilson), a general surgeon who becomes the hospital's Chief Resident and later applies for a pediatric surgery fellowship. The surgical program is run by Chief of Surgery Richard Webber (James Pickens, Jr.) who has a pre-existing personal relationship with Meredith, having had an affair with her mother when Meredith was a child. In Webber's employ are attending physicians Derek Shepherd (Patrick Dempsey) and Preston Burke (Isaiah Washington), who specialize in neurosurgery and cardiothoracic surgery respectively. Derek is introduced as Meredith's love interest, while Preston begins a relationship with Cristina, who ultimately leaves him at the altar.

Introduced in the show's second season are OB-GYN and neonatal surgeon Addison Montgomery (Kate Walsh), plastic surgeon Mark Sloan (Eric Dane), orthopedic surgeon Callie Torres (Sara Ramírez) and cardiothoracic surgeon Erica Hahn (Brooke Smith). Addison is Derek's ex-wife who arrives in Seattle seeking a reconciliation with him. Walsh left the series in its third season to star in spin-off Private Practice, but continues to make occasional guest appearances in Grey's Anatomy. Mark is Derek's former best friend, who aided in the breakdown of his marriage by having an affair with Addison. Callie is introduced as a love-interest for George, who she later marries, but ultimately divorces. Erica replaces Preston as head of cardiothoracic surgery and begins a lesbian relationship with Callie; however, she leaves abruptly in the show's fifth season.

The fourth season introduces intern Lexie Grey (Chyler Leigh), Meredith's half-sister. She forms a fast friendship with George, and harbours romantic feelings towards him which go unreciprocated. She later embarks on a relationship with Mark. A second intern, Sadie Harris (Melissa George) is introduced in the show's fifth season; George, however, did not go on to become a series regular, criticizing the show's writers for severely restricting her character's growth. Also introduced in the show's fifth season are trauma surgeon Owen Hunt (Kevin McKidd), cardiothoracic surgeon Virginia Dixon (Mary McDonnell) and pediatric surgeon Arizona Robbins (Jessica Capshaw). Owen becomes a love-interest for Cristina, Richard attempts to convince Virginia to replace Erica as head of Cardiothoracics and ultimately fails, and Arizona becomes a love-interest for Callie.

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