Total synthesis of lysergic acid via Pd-catalysed domino cyclizations

The synthesis of lysergic acid by Shinsuke Inuki et al, which uses a neat palladium-catalysed reaction, and provides the opportunity to look at the Woodward-Hoffman rules for a Claisen rearrangement. Org. Lett 2008, 10, 22, 5239-5242

Category:

Science & Technology

Tags:

• chemistry
• LSD

[BrianGValentine]

I have now convinced myself that the fluoborate complex was used because the configuration leaves a δ+ on the oxygen atom

I would not have thought of using it

[BrianGValentine]

The [(φ3 P Au3])3 O] fluoborate complex must have its own stereochemistry

[shambrawk]

@pumitaproductions none taken. I guess I meant I wanted them to delve into whats going on in the reactions very thoroughly, which, I suppose, means spoon fed. I don't think you will ever find MDMA or LSD from any spoon fed highschoolers anyways. You would have to find a way of obtaining the precursor chems, necessary reaction vessels, or you would have to build your own lab equipment and synth your own precursors, a ridiculously daunting and time consuming task.

[pumitaproductions]

@shambrawk No offense, but I wouldn't want MDMA or LSD knowing it was from a high-schooler who wanted Organic Chemistry spoon fed. If you really want to make these, buy a couple organic textbooks and read them. Or take classes in your college.

[collectivemind513]

<3

[shambrawk]

I love the new graphics. You should make videos that are not so fast, I guess this is focused towards people who already understand basics in chemistry, but it would be awesome if you had videos explaining the basics in a way a high school graduate could understand. I mean, all of these are illegal drugs, maybe you could teach us how to synth something very simple and explain it as much as possible.