Resveratrol Video, 60 Minutes, CBS News

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Morley Safer:
Now, scientists across the country have identified a substance in red wine called resveratrol that they believe might do more than just protect the heart, but could — in very high concentrations — significantly extend life by preventing a number of age related illnesses. If they're right, we all may soon be taking a pill that could give us an extra decade or two of healthy old age.

Dr. Christoph Westphal, Sirtris Pharmaceuticals:
If the promise holds true, I think this has the chance to change healthcare.

Morley Safer:
Dr. Westphal says we all may soon be taking a drug that just might beat the clock, a simple pill that could delay the inevitable.

Dr. Christoph Westphal, Sirtris Pharmaceuticals:
Our goal is to prevent and forestall many of the diseases that strike us as we reach 50, 60, and 70. All with one pill.

Morley Safer:
What you're suggesting that it's some kind of a rejuvenation drug that turns a 70-year-old into a 35-year-old.

Dr. Christoph Westphal, Sirtris Pharmaceuticals:
That might be pretty hard to do. But I think if we're on a train heading one direction, we can slow down that train. I think we can slow down these genes that control the aging process.

Morley Safer:
That quest to put death on hold began in 2003 when Westphal met David Sinclair, a biochemist at Harvard who was studying the genetic components of aging.

Dr. Christoph Westphal, Sirtris Pharmaceuticals:
Five years ago I met David. And he had shown that you could extend life span in yeast. That's pretty exciting.

Morley Safer:
If you happen to be a yeast, that's pretty exciting. Yeasts are one thing. Human beings are more complicated. So Sinclair focused on a gene present in almost all life forms: the sirtuin gene. It's normally inactive, but when it is active, Sinclair believes it triggers a survival mechanism that extends life. Convinced that something in nature could activate that gene, Sinclair randomly tested thousands of compounds and bingo — got a hit: resveratrol...

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