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The Highs and Lows of EGFR

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Uploaded on Aug 4, 2010

The binding of epidermal growth factor (EGF) induces dimerization and activation of its receptor, EGFR. Watch as Mark Lemmon and Diego Alvarado take you on a brief, personally guided tour of their findings that low-affinity receptors are generated by asymmetric ligand binding and negative cooperativity.

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