生長激素~在~年老卵子~作用是什麼？gh

生長激素在年老卵子作用是什麼？

How Dose Coenzyme Q10 Supplementation During Infertility Treatment Effects Pregnancy Outcome (CoQ10)
This study is not yet open for participant recruitment.
Verified by University of Toronto, April 2009
First Received: April 7, 2009 No Changes Posted
Sponsors and Collaborators:University of Toronto
The Toronto Center for Advanced Reproductive Technology (TCART)
Ferring Pharmaceuticals

Information provided by:University of Toronto
ClinicalTrials.gov Identifier:NCT00878124

Purpose
As women age the ovarian response and pregnancy rate are reduced while the rate of chromosomal abnormalities in the embryos is increased. Oocyte maturation, accurate chromosomal segregation as well as early embryo development and implantation are dependent on the supply of large amounts of energy, which unlike other cells can only arise from the mitochondria. With age the mitochondria becomes less efficient due to damage to its unique DNA, resulting in decreased energy production. The proposed study will examine the effect of the combination of a dietary supplement, Co enzyme Q10 on pregnancy rate and response of the ovaries to a medication that stimulates follicle growth. The investigators hypothesize that the improved energetic state of the oocyte would result in a more accurate chromosomal separation, increased embryo quality and pregnancy rate.


ConditionIntervention
Poor Ovarian Response
Dietary Supplement: Coenzyme Q10 co treatment
Other: Placebo Caps



Study Type:Interventional
Study Design:Prevention, Randomized, Double Blind (Subject, Caregiver), Placebo Control, Parallel Assignment, Efficacy Study
Official Title:The Influence of Concomitant Co Enzyme Q10 Use on Pregnancy Outcome in Intrauterine Insemination

Growth Hormone Co-stimulation May Improve Outcome in Patients with Multiple IVF Failures
May 18, 2009A greater understanding of the role of growth hormone (GH) in augmenting the ovarian response to gonadotropins has encouraged researchers to explore the use of GH as an adjuvant treatment for ovarian stimulation. In a recent retrospective study published in the journal, Reproductive BioMedicine Online, researchers have provided further credence to the potential of GH co-stimulation with recombinant follicle stimulating hormone (FSH) or human menopausal gonadotropin (HMG), in enhancing the IVF treatment outcomes in patients with history of repeated ART failures.
In the study conducted by Andre Hazout from the ART Unit Eylau-La Muette, Paris and coworkers, a protocol with 8 International Units (IU) of GH was evaluated in 291 patients who had ≥3 previous failures of embryo transfer without any clearly identifiable etiology. Of these subjects, the researchers analyzed only those patients (n=245) whose protocol included FSH or HMG, apart from GH. In the observational study design, the results obtained were compared retrospectively with that of the patients (with ≥3 failures) who were stimulated only with FSH or HMG, without GH.

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