Using Dendritic Cells to Create Cancer Vaccines

November 13, 2007 presentation by Edgar Engleman for the Stanford School of Medicine Medcast lecture series.

Edgar Engleman, MD, medical director of the Stanford Blood Center, discusses his research involving the use of a special type of white blood cell as a treatment for cancer. Engleman, who is also a professor of pathology at the Stanford School of Medicine, and his team of researchers have been interested in dendritic cells, or DCs, which can provoke an immune response in the body.

Stanford University School of Medicine:
http://med.stanford.edu/

Stanford University Channel on YouTube:
http://www.youtube.com/stanforduniversity

Category:

Education

Tags:

• medicine
• health
• cancer
• vaccine
• treatment
• Stanford
• Blood
• Center
• pathology
• dendritic
• cells
• immune
• system
• antibody
• white
• blood
• tumor
• clinical
• trials
• immunotherapy
• effector
• receptors
• ligands
• recognition
• specificity
• chem

[sn1pe352]

NOTE :

Dr. Cassian Yee, Drs. Zihai Li and Bei Liu,, William Coley, Victor Ambros, Gary Ruvkun, and David Baulcombe

Researchers have uncovered a way to potentially use human stem cells as a kind of vaccine against colon cancer.

This discovery, led by experts in immunology, Drs. Zihai Li and Bei Liu, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumor response by "fooling" the immune system into believing that cancer cells are present.

[grunder20]

Props to Stanford for making a documentary.

[agapitoflores001]

This is a great breakthrough. It will give hope to many people.

[ILMEDICINE]

good

[MannyHMo]

@tortaros

Very clear and thought provoking indeed !

[MannyHMo]

@vitormangraviti

I know Dr. Cesar Milstein is from Argentina; then went to the U.K. He won the Nobel Prize (with some other scientists) for his work on this field of monoclonal antibodies. Talent is everywhere really. The U.S. just happens to be the 'rich boy' on the block who can attract a lot of talents, the funding, and the free environment to let the mind wander. This monoclonal antibody was produced from hybrid cell (hybridoma) - cancerous myeloma cells and plasma cells.

[MannyHMo]

Dr. Engleman, I'm wondering if an antibody can be created specific against PSA. All cases of prostate cancer have tremendously high PSA. This antibody will 'disrupt' this PSA producing cancer cells somehow. I think the PSA in all of these cases are the same and it doesn't have to involve making antibody to PSA for each specific patient. Just wondering if anti-PSA antibody has been created or induced.

[vitormangraviti]

This vaccine has been invented by a Brazilian. He's actually patented it and did it as a "public patent". So anyone can use it without having to pay royalties.

Search for A Barbuto on Google and you'll see his documents online.

It's not an American thing. Stop taking credibility for everything good in the world. That is so not true.

[tortaros]

well done lecture !

[vitaminboss]

The FDA and Pharma are in bed together. Polyclonal antibodies would be much more efficient therapeutically. They know very well that the body is too complex too respond to single agent drugs and drug targets. Its their narrow-minded (possibly deliberate) stubborness that is stifling progress in cancer therapy. They WANT to keep chemo as standard therapy. Why? Because using chemo makes this industry a $200 billion per year industry. The drugs required to manage side effects are several, & pricey