MDAI - Chemistry Behind the Headlines 3

This video describes how chemists actually go about investigating the activity and toxicity of psychoactive drugs. I talk about the behaviour and activity of MDAI. Most of the discussion in this video could also be directly applied to 6-APDB. We discuss what is meant by the reported 'low neurotoxicity' of these drugs, but then go on to consider how cardiotoxicity is the big unknown for these type of serotonin-modifying compounds. Music by Marillion (Happiness is the Road).

Category:

Science & Technology

Tags:

• MDAI
• 6-APDB
• cardiotoxicity
• neurotoxicity
• fenfluramine
• serotonin
• clinical trials
• chemistry
• drugs
• research
• pharmaceutical

[cigarboxblues]

How can this report possibly be accurate when you are using Nicholl's research on 3,4-Methylenedioxyamphetamine (MDA) CAS number 4764-17-4 not 5,6-Methylenedioxy-2-aminoinda­ne (MDAI)CAS number 132741-81-2. These are two completely different chemicals and your misinformation could do more harm than good!

[ProfessorDaveatYork]

@cigarboxblues

The paper I used which carries out the cardiotoxicity study does discuss and focus on MDAI (although other potential drugs are also considered in it too) - I am well aware of the difference between MDA and MDAI and was careful in navigating the scientific literature to avoid this confusion.

[tru7hhimself]

good video that explains it well to anyone not capable of reading the original papers .

i'd still like to add a point: mdma is a (more of less) potent agonist at 5-HT2B, but doesn't cause widespread cardiac valve fibrosis like fenflouramine, because it's used occasionally as opposed to daily which was the case with prescribed fenf.

so i'd expect daily mdai use to be problematic (because of probable 5-HT2B agonism and 5-HT release), but recreational use ok. of course further research is required.

[ProfessorDaveatYork]

@tru7hhimself This is a fair comment. Interestingly, a paper in International Journal of Obesity (1999, 23, 926-928) indicated that the risk of cardiotoxicity of fenfluramine was dose dependent. Patients who take >60 mg/day were at higher risk than those taking <40 mg/day. Of course MDAI and fenfluramine are completely different drugs - but the typical dose of MDAI is significantly higher at 100-200 mg. The cardiotoxicity risk would then depend on how regular the recreational use is.

[1giblesp]

If MDAI is banned, the manufacturers will release something else as a 'legal high.'

The government policy of criminalizing drugs is a waste of money and in effect, leads to people trying other potentially more dangerous drugs marketed as legal.

Ecstasy taking is a part of mainstream culture. It would be far safer for young people to take something that was regulated, with clear warnings, rather than take an unknown pill form a street drug dealer.

[emsagro12]

Personally I doubt that there will ever be such a problem with occasional use of MDAI, but purity is another concern. In the absence of regulations, I would not be surprised if manufacturers have no clue what they are doing, and online dealers cut the substances with whatever they have in store.

[HonorEtFides]

Excellent and informative video.

Note: If you are going to use music from an independent band that publishes under its own record label, then please give them the appropriate credit in your opening comment as you did in some of your other videos.

[TroutMaskReplicaa]

It's odd that, in a supposed civilised and intellectual society, anything deemed a drug is immediately demonised and pounced upon. The government use it as an excuse to peddle more of their scaremongering tactics... indoctrinating a dissatisfied public with fear. It isn't odd that the whole mephedrone debacle happened around an election shifting public opinion off unemployment, recession and toward a 'scary, scary drug that will kill you if you even touch it'. Drugs aren't intrinsically harmful.

[bloddyjoka]

@1giblesp free the weed

[SolutionDevil]

cool laptop bro

[sjingelling]

you are great!! acurate info , thx for sharing your knowledge ^^ i just love it

[FractalRaver]

@cigarboxblues

So this guy is talking about MDA, instead of MDAI? Huge difference (dopamine release). MDA is even more dopaminergic than MDMA.

[nadskofhqwak]

i binged hardcore on this shit for 3 days. tried to commit suicide afterwards.. the comedown is just as horrible as e's comedown

[SethJosephThompson]

Makes me sad that fen phen was banned was an amazing treatment for autism spectrum disorders.

[poztpwned]

Awesome video my man. Awesome information about the 5-HT(2b) receptor activity, brought some important info to my attention that should be brought to others' attention as well (unless they want to risk their own heart).