Histopathology Bone--Paget disease
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COMPARATIVE VIDEOS RULEZZ
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hahah, I wish I was in your class, my pathology seminars were soo dull, I like this very much, thanks
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Great pathologic description; incorrect pathophysiology. Paget disease is initiated by increased osteoclast activity. The osteoclasts have increased number of nuclei, have nuclear inclusion bodies(of viral origin?), & are hyperactive. Primary abnormality in Paget disease is intense resorption. The osteoclastic resorption causes increased osteoblast activity and disorganized bone. Molecular defects described in Paget disease affect the osteoclast (RANKL/RANK receptor mutations).
rfgagel 3 years ago 10
Osteoblasts... Gone... Wild!
LOL... Thanks so much! This help out a lot for my test next week. Pulled together the information well. Loved it.
LambdaLady07 2 years ago