Part 3 of 5 - The Ghost in your Genes - BBC Horizon

Biology stands on the brink of a shift in the understanding of inheritance. The discovery of epigenetics hidden influences upon the genes could affect every aspect of our lives.
At the heart of this new field is a simple but contentious idea that genes have a 'memory'. That the lives of your grandparents the air they breathed, the food they ate, even the things they saw can directly affect you, decades later, despite your never experiencing these things yourself. And that what you do in your lifetime could in turn affect your grandchildren.
The conventional view is that DNA carries all our heritable information and that nothing an individual does in their lifetime will be biologically passed to their children. To many scientists, epigenetics amounts to a heresy, calling into question the accepted view of the DNA sequence a cornerstone on which modern biology sits.
Epigenetics adds a whole new layer to genes beyond the DNA. It proposes a control system of 'switches' that turn genes on or off and suggests that things people experience, like nutrition and stress, can control these switches and cause heritable effects in humans.
In a remote town in northern Sweden there is evidence for this radical idea. Lying in Överkalix's parish registries of births and deaths and its detailed harvest records is a secret that confounds traditional scientific thinking. Marcus Pembrey, a Professor of Clinical Genetics at the Institute of Child Health in London, in collaboration with Swedish researcher Lars Olov Bygren, has found evidence in these records of an environmental effect being passed down the generations. They have shown that a famine at critical times in the lives of the grandparents can affect the life expectancy of the grandchildren. This is the first evidence that an environmental effect can be inherited in humans.
In other independent groups around the world, the first hints that there is more to inheritance than just the genes are coming to light. The mechanism by which this extraordinary discovery can be explained is starting to be revealed.
Professor Wolf Reik, at the Babraham Institute in Cambridge, has spent years studying this hidden ghost world. He has found that merely manipulating mice embryos is enough to set off 'switches' that turn genes on or off.
For mothers like Stephanie Mullins, who had her first child by in vitro fertilisation, this has profound implications. It means it is possible that the IVF procedure caused her son Ciaran to be born with Beckwith-Wiedemann Syndrome a rare disorder linked to abnormal gene expression. It has been shown that babies conceived by IVF have a three- to four-fold increased chance of developing this condition.
And Reik's work has gone further, showing that these switches themselves can be inherited. This means that a 'memory' of an event could be passed through generations. A simple environmental effect could switch genes on or off and this change could be inherited.
His research has demonstrated that genes and the environment are not mutually exclusive but are inextricably intertwined, one affecting the other.
The idea that inheritance is not just about which genes you inherit but whether these are switched on or off is a whole new frontier in biology. It raises questions with huge implications, and means the search will be on to find what sort of environmental effects can affect these switches.
After the tragic events of September 11th 2001, Rachel Yehuda, a psychologist at the Mount Sinai School of Medicine in New York, studied the effects of stress on a group of women who were inside or near the World Trade Center and were pregnant at the time. Produced in conjunction with Jonathan Seckl, an Edinburgh doctor, her results suggest that stress effects can pass down generations. Meanwhile research at Washington State University points to toxic effects like exposure to fungicides or pesticides causing biological changes in rats that persist for at least four generations.
This work is at the forefront of a paradigm shift in scientific thinking. It will change the way the causes of disease are viewed, as well as the importance of lifestyles and family relationships. What people do no longer just affects themselves, but can determine the health of their children and grandchildren in decades to come. "We are," as Marcus Pembrey says, "all guardians of our genome."

Category:

Science & Technology

Tags:

• BBC
• Horizon
• Ghost
• Genes
• Inheritance
• Biology
• Science
• Relation
• epigenetics
• histones
• genome
• nutrition
• stress

[SamaiJaiIndr]

step by step, we are finding ways to look deep into nature. in this particular chapter, 'written record' would show its true benefits more than a hundred years past.

[withoutmercyuk]

how this will relate to GMO crops?? What genetic info are we consuming? Human genes are inserted to bovine to produce human milk. Will that now operate a switch in the humans who drink that milk? Has to, because the mice born from a tampered with adult carried to next generation. wow! crazy!

[maugustyniak]

Moral of this story: If you're not reproducing normally. nature wants you dead.

[VaRose1]

@Andre2Dayle

DNA is packaged into a chromosome.

When DNA is tightly packaged into a chromosome, transcription proteins cant access the DNA.

When parts of the DNA are loosely packaged the transcription proteins can access the DNA to make RNA.

So this video is talking about how the packaging of DNA can be inherited and change the way an organism looks or functions. The changes in packaging can be a result of environmental factors.

Watch "On epigenetics (part I)" - its helpful

[ovyboia]

it makes darwin theory more believable... cos that thingy about random mutations that are Randomly better adapted to the entorn didnt sound completely right.

[acidwashedgenes]

@Andre2Dayle watch part 1!

[Andre2Dayle]

can someone Explain all this to me as easy as possible ???

[bpine20]

@bpine20: Oh, sorry, just watched Part 4.

@CooCurrent: Thank you for posting these videos!

[bpine20]

Okay, I have a question: The women near the end talks about how the experience of the holocaust effect the grandchildren and children of the survivors, but what were those symptoms? If it's just that they worry (no pun intended, please understand) couldn't that be due more to sociological/lifestyle reason then genetics?

[PaulDiracFRS]

What is the mechanism whereby these life-experiences are transmitted to the egg cells? I am under stress; stress is caused by heightened or reduced levels of some hormone; the egg cells then pick up on this? How do the hell do the chromosomal genes in the egg cells know which experiences are relevant to their on-off states?