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Hugging Tightly: Human RNase Inhibitor

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Uploaded by on Aug 25, 2009

RNase secreted from pancreas is necessary to digest RNA in diet to utilize as nutrients, but if they happen inside cells, it could disrupt crucial cellular functions. Human ribonuclease inhibitor is a horseshoe-shaped protein and inhibits human pancreatic ribonuclease by tightly hugging and completely blocking the active site of the enzyme. This complex is one of the tightest intermolecular interactions known (1Z7X.pdb ref. Johnson et al. JMB v368 p434).

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  • the film makes me want to throw up

  • RI is a beautiful structure

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