Inside the Cancer Cell (from PBS' Curious)

Experimental cancer drug IT-101 releases campothecin into cancer cells for effective treatment. We used a whole lot of trickery to make this piece for the PBS mini "Curious". The whole episode for which we did loads of graphics is at thirteen.org/curious . Animated by Jordan Bruner

Category:

Film & Animation

Tags:

• animation
• asterisk
• documentary
• science
• experimental
• cancer
• PBS
• jordan
• bruner
• painterly

[bellcms]

How does IT-101 target only cancer cells?

[asteriskpix]

It exploits the "shoddy" structure of cancer cells. The nature of cancer cells is that they grow quickly -in doing so their construction is poor. The cells' blood vessels are full of large wholes.

IT-101 is a large molecule which delivers Campothecin (that's the theraputic drug) . The molecule is too large to attack healthy cells, but fits right into a cancer cell.

[gadionson1]

yeah .. super interesting ...

[jhmoonman]

Really interesting !!!

[piepiedish]

@XX1goodhalo2playaXX the it-101 would appear as a sugar to the body, as such white blood cells will not respond to them as a threat and hence they will not engulf it-101

[XX1goodhalo2playaXX]

wouldn't the white blood cells undergo phagocytosis on the it-101

[EyesOfPower10Y]

the shape of vessales reminded me abt some thing ...Do u know why cancer is called like this "Cancer"... that's because the vessels suroundin the tumor " the crazy incontroled cells" make at the end a cancer's shape

May God prevent all of us from it :)

Thx for the post