The First Responder in an Emergency: Mre11 Dimer Binding to Broken DNA

DNA double-strand breaks induced by genotoxic agents or at stalled replication forks are detected by MRN (Mre11-Rad50-Nbs1) complex. The Mre11 is the first one to rash at the site and to bind and process the ends to facilitate homologous recombination. The synaptic complex shows Mre11 dimer in the symmetrical binding to both broken DNA ends. The branched DNA complex shows Mre11 dimer in asymmetrical binding to the collapsed DNA fork (3DSC.pdb and 3DSD.pdb; Ref. Williams et al. Cell, v135, 97).

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Science & Technology

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• gene
• music
• DNA
• break
• repair
• protein
• Mre11
• Munakata
• Nobuo
• Max
• Jitter