A Glimpse of the RNA World: Ribozyme RNase P Bound with tRNA

Ribonuclease P (RNase P) is a ribonucleoprotein complex responsible for processing many different RNA molecules in the cell. The RNA component is responsible for hydrolytic cleavage of substrate RNA and thus could be considered as a remnant of an ancient RNA-based world before the emergence of DNA and proteins. The structure of RNase P involved in the maturation of the tRNA substrate exhibits the major recognition occurs by shape complementarity, intermolecular contacts and base-pairing interactions (Ref: Reiter et al. Nature vol 468, 784: 3OK7.pdb).

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• ribozyme
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