DNA Replication Licensing and Inhibition: Cdt1-Geminin Complex

DNA replication during S phase should occur only once for each segment of eukaryotic chromosome. Cdt 1 protein is a key component for the assembly of prereplicative complexes. The structure of Cdt 1 and two Geminin molecules can exist in two distinct forms, a permissive heterotrimer and an inhibitory heterohexamer, in which specific Cdt 1 residues important for the licensing are buried in the complex (2WVR.pdb: ref. De Marco et al. PNAS v. 106, 19807).

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Science & Technology

Tags:

• gene
• music
• video
• DNA
• replication
• licensing
• inhibition
• Cdt1
• Geminin
• complex
• Nobuo
• Munakata
• MaxMsp
• Jitter
• Absynth
• Metasynth