EF - Tu

"Elongation factor Tu has three domains, which are compactly arranged in its GTP-bound state. Here we show the surface of the protein with each of its domains in a different color. Regions of all three protein domains contribute to the tRNA binding site. An important dynamic element in the structure of elongation factor Tu is the switch helix. As GTP is hydrolyzed and the gamma phosphate is released, the switch helix rearranges. This in turn leads to a major structural rearrangement of the three protein domains, which disrupts the tRNA binding site. Thus upon GTP hydrolysis, the tRNA is released from elongation factor Tu."

Essential Cell Biology, Second Edition
by Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, Walter
copyright 2004 by Garland Science Publishing

Category:

Science & Technology

Tags:

• EF-Tu
• elongation
• factor
• Tu
• GTP
• guanosine
• triphosphate
• tRNA
• helix
• hydrolysis
• cell
• biology
• biochemistry
• science

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