Stephen Mayo (Cal Tech) Part 1 Protein Design by Computation

In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high mutation rate (to explore a diversity of function) while maintaining stably folded structures (a necessity to preserve stability and function). See more at http://www.ibioseminars.org

Category:

Science & Technology

Tags:

• protein
• protein design
• computational design
• protein structure
• protein fold