Neutrophil Adhesion Migration and Phagocytosis

A neutrophil travels along the capillary endothelial layer. Endothelial cells are triggered to express selectins on their surface for neutrophil integrin-mediated adherence. Transendothelial migration allows the neutrophil to traverse the blood endothelial layer. Squeezing into the extra-capillary space where migration towards a chemotactic gradient (chemotaxis) helps it to locate the pathogen. Subsequent phagocytosis ensues.

Category:

Film & Animation

Tags:

• Neutrophil
• Phagocytosis
• Chemotaxis

[rosygirls92]

What is the importance of neutrophil adhesion anyway?

[Contourgreg]

@rosygirls92

Adhesion is necessary for the circulating non-activated phagocyte (white blood cell) to take on an active phenotype. The endothelial cells lining the blood vessels become activated to express various selectins and adhesion molecules on their surface in response to bacterial/microbial stimuli. The circulating white blood cells counter receptors recognize the inflamed epithelium, allowing the white blood cell to stick or adhere to the epithelial surface and transmigrate through it.

[babbyluvin]

not like am complaining or owt but it could do with volume :)  xx

[Contourgreg]

sorry. I'm not much of a narrator.

[wolfapostle]

Normally extravasion/migration takes place in the post-capillary venules right? Only in some cases this occurs in the capillaries.

Nice video btw.

[Contourgreg]

you got it.  Thanks.

[cyrusrom]

it`s no phagocyte it`s a granulocyte types of granulocyte neutrophil, basophil eosinophil

[cyrusrom]

it`s bo phagocyte it`s a granulocyte types of granulocyte neutrophil,basophil and eosinophil

[sarrosita]

a neutrophil is a type of early responding phagocytic cell, they can be easily differentiated from monocytes/macrophages (other phagocytic cells) by their tri-lobed nucleus. After phagocytosing, neutrophils die and they form the pus you see on wounds.

[indyk91]

i dont understand, i havnt heard the term neutrophil before, is that another term for phagocyte? and if not whats the difference?