How Suboxone Works Part One

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Uploaded by on Jan 6, 2009

Buprenorphine, the active ingredient in Suboxone, has a unique action at the receptor that puts addiction into remission. This video explains how buprenorphine differs from opiate agonists like heroin, methadone, and oxycodone.

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Uploader Comments (SuboxDoc)

  • Nice work out the basement. I love your office..

  • Thanks!  What's with the 'Norwegian black metal'?

  • DR. Jeff...YOU LOST ME AT "When WE were monkeys?"

  • Evolution speaking, that is!

  • LOL - *loads* of people inject Suboxone. Check out the bluelight (other drugs) forums if you don't beleive me.

    The naloxone doesn't work when injected, as the bupe has a higher affinity for the receptors and out competes it.

    Its basically inert.

  • I know Bluelight well-- people do all kinds of things! But I have a good handle on use in my part of the country, and heroin and OC are what people are injecting-- far more than bupe. I have always said that the naloxone is more political than practical, but it WILL precipitate W/D in many people-- it depends on their opiate tolerance among other things. Affinity is only half of the equation. A low-affinity drug will displace a high affinity drug if the dose is high enough.

Top Comments

  • why does it have to cost so much? i could be the poster child for this stuff.. but i have only been able to buy it off people i know.. to see a doctor for it is WAY WAY TOO EXPENSIVE. but this stuff works. it really works. why don't they make this more readily available to people that really wanna quit?

  • I take this daily. Its the best thing that ever happened to me. Been clean for so long.

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All Comments (30)

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  • i dont think chimps have arms lol(: great video.

  • If your never been on opiates and addicted to it you and anyone els will never NEVER know till you have gone through it !

  • Just to clarify, it has naloxone, not naltrexone. Naltrexone is active orally, and naloxone is not. You are correct about the pharmacist situation-- Subutex vs Suboxone are interchangable. Neither is 'indicated' for pain in the US, but bupe IS used for pain in other countries. She is incorrect about using one for pain and not the other; there is no such issue, as the naloxone is not active when taken orally and is therefore irrelevant to the issue.

  • Sorry for the delay--- as you learned, they won't do that-- Suboxone and Subutex are different meds and pharnacists cannot replace one with the other. You are correct on your second comment--

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