microRNA formation and function
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follow the schema (step by step): wikipedia*org/wiki/File:MiRNA-
biogenesis.jpg when you are watching that animation. -
It is very nice,It would be better if each step was explained.
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Very nice video - can I please have a copy to show to my students?
Thanks
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The inhibitory RNA is not ssRNA; it is an antagomiR, like LNA or 2'O-Me. It can be delivered directly to cells.
In mammals, generally miRNA-loaded RISCs don't proceed through Slicer mechanism to amplify the inhibitory response. Only in lower organisms.
The yellow thing is RISC.
Wished they would distinguished pri-, pre-, duplex, and mature miRNA. Also, where's Drosha/DGCR8? I guess good enough for lay people.
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This is fairly accurate but it doesn't show miRNA's ability to influence Slicer and Dicer to break up the mRNA, as well as amplify the inhibitory response.
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Why there is no sound on this Vids? Anybody can help?
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Anything on inhibitory RNA
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looks like a loaf of bread to me :D
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It is very informative. It would be better if every step was explained verbally.
Sarmastani 1 year ago 6
that is the argonaute protein, an endonuclease that binds to the microRNA and causes part of its function, the degradation of the messenger RNA. There are also other proteins that help in the mRNA degradation/inhibition of protein translation, such as TRBP and Dicer itself (which cleaves the hairpin precursor into the mature microRNA) and together with the argonaute (aka Ago) they form the RISC complex (RNA induced silencing complex) that is in charge of doing those functions.
scientificallyunstab 2 years ago 2