MDTV: Parkinson's Disease Dementia

"Parkinson's Disease Dementia" featuring Neurologist, Dr. Dee Silver, discusses how Parkinson's patients are 4 to 6 times more likely to develop some cognitive impairment. Up to 1 million people in the US are affected by IPD. After patients have had the disease 8 to 10 years, they have about an 80% chance of developing cognitive impairment. Dr. Silver talks about a new drug (Excelon) that is shown to hold off these impairments.
Series: "MDTV (Medical Doctor Television)
" [12/2007] [Health and Medicine] [Show ID: 13686]

Category:

Education

Tags:

• parkinson's
• disease
• health
• dimentia

[mdrummond7]

Amyloid plaques contain central Fe which produces superoxide via fenton reaction, which cause lipid peroxidation and subsequent damage to proteins and DNA. Amyloid also can bind to scavanger receptors enhanceing cdk5 activation, leading to apoptosis activation and tau phosphorylation i.e neurofirbillary tangles. Also via similar mechanisms they can cause inflammation leading to the release of cytokines NO etc. it can lead to glutamate hypersensitivity leading to excitotoxicity.

[Larabela24]

Very well explained thank you for this video.

[1PeaceNation]

i am scared of parkinsons.

[janesatorres]

Then having parkinson's for some time is a sign of a brain problem later in life. It only means it should be constantly monitored.

[amazingdany]

Prevent Parkinson and dementia with supplements!

Go on Amazon U.S., buy these:

- Life Force Multiple 35$/ bottle 2 pills at breakfast, 2 at dinner, one bottle last 45 days.

- Swanson CoQ10 8$ for 100 pills (cheapo and hi quality): 1 each day, take 3 if Parkinson's or dementia-plagued (will unfortunately NOT cure but maybe reduce pain, MAYBE).

- Swanson grape seed extract 100 mg 5$ for 120 or so pills, same dosage as the CoQ10.

Yearly expenses for prevention and good health: < than 350$!

[mdekq007]

@megghegg I was just about to say I think exelon are paying this guy off

[megghegg]

Great. Another Drug Commercial - Now on YouTube.

[pochlomin]

Thanks

[mdrummond7]

Genetic cuases of Alzheimers tend to be primarily associated to the much rarer form of young age onset. However, for normal predominantly idiopathic Alzhiemers Apolipoprotien epsilon has been implicated in predisposing to it. As far as this gene is concerned it contains two single nucleotide polymorphisms, with 4 identified versions of the gene in humans. However as I'm not an expert in gene thrapy I wouldnt know how to go about altering it, other than just inserting a new copy of a benine form

[mdrummond7]

In reguards to current medication unfortunately there isn't much available, as essentially they treat the symptoms rather than the cuase, so deteriation will still occur. As far as antioxidants go lipoic acid seems like a pluasable option as can upregulate endogenous antioxidants (nrf2-keap1 system) and seems to act as an iron chelator. (also see curamin). However I wouldn't expect an improvment of symptoms, rather retard the deteriation in brain function. hopefully that helped a little?

[MoreFaithNo]

Would you endorse taking R-Lipoic Acid to combat central Fe. My father is getting into the later stages (about 7-10 years of known symptoms) and I can see that his memory is losing ground. Is there anything that can try to cut to the source of the deterioration instead of just squeezing more dopamine out of his brain with current meds. Thanks!

[cXzndModCon]

Hi mdrummond. Maybe, but is there any possibility of salvage due to genetic wobble ?