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Published on Mar 10, 2014
In this lecture we cover intrinsic and innate immune defenses. Intrinsic defenses, such as apoptosis, autophagy, and antiviral proteins like APOBEC3G, are available at all times in uninfected cells. Innate defenses, in contrast, are induced when the cell senses the presence of a pathogen, with toll-like receptors, cytoplasmic helicases, and other sensors. The output consists of cytokines, including interferon, which in turn induces antiviral proteins. Cells of the innate response include dendritic cells, macrophages, and NK cells. Finally we consider how a strong innate response, coupled with inflammation, is essential for a robust adaptive response.