Amyotrophic lateral sclerosis is an adult-onset, disabling and fatal disease characterized by progressive degeneration of motor neurons in brain and spinal cord. No cure is available for ALS and the median survival is 3 years. The main objective of our research proposal is to initiate a research line that translates recent successes in ALS genetics into functional studies, to identify pathogenic pathways and targets for treatment for our patients suffering from this progressive fatal disease.
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