A hydrophobic spring regulates human PGK

The catalytic cycle of human phosphoglycerate kinase is regulated by a hydrophobic "spring". Human phosphoglycerate kinase is responsible for energy generation in metabolism and the phosphoryl-transfer activity of PGK is important in the processing of anti-retroviral pro-drugs that take the form of L-nucleoside analogues effective against HIV and hepatitis. The protein cycles between open and closed conformations to produce the molecule ATP, a universal energy currency in cells. On domain closure a hydrophobic patch (yellow) is exposed to solvent ensuring that after catalysis the products are efficiently released.

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