什麼是~~雞尾酒~~黃體素療法?

什麼是雞尾酒黃體素療法
Hum Reprod Update. 2007 Nov-Dec;13(6):581-90. Epub 2007 Jul 11.

An update of luteal phase support in stimulated IVF cycles.
Fatemi HM, Popovic-Todorovic B, Papanikolaou E, Donoso P, Devroey P.

Centre for Reproductive Medicine (VUB/CRG), Dutch-Speaking Free University Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium. hmousavi@uzbrussel.be

Stimulated IVF cycles are associated with luteal phase defect. In order to overcome this, different doses, durations and types of luteal phase support (LPS) have been evaluated. There is still no agreement regarding the optimal supplementation scheme. The aim of this paper is to assess the past and the current clinical practices of luteal supplementation in IVF. The databases of Medline and PubMed were searched to identify relevant publications. LPS with human chorionic gonadotrophin (hCG) [n=262, odds ratio (OR) 2.72 (95%), confidence interval (CI) 1.56-4.90,


but not in the short GnRH agonist and GnRH antagonist protocol. Despite the early promising results, it is too early to recommend the use of GnRH agonist in LPS. LPS should cease on the day of positive HCG. Since the cause of luteal phase defect in IVF appears to be related to the supraphysiological levels of steroids, milder stimulation protocols should be advocated in order to eventually overcome the luteal phase defect.

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