HCV Life Cycle.flv

Life cycle of Hepatitis-C Virus (HCV), the leading cause of chronic liver disease, begins with its entry into the hepatocyte via receptor-mediated endocytosis. Once released inside the cell, single stranded HCV RNA is used as a blueprint for the production of viral proteins, which helps in replication of HCV RNA. The new positive-sense progeny HCV RNA is encapsidated with the structural proteins. Finally, infectious virions are released to infect new cells. HCV does not kill the cells it infects, but triggers an immune mediated inflammatory response (Hepatitis) that either rapidly clears the infection or slowly destroys the liver. This animation gives a brief description of the HCV replication inside the hepatocyte.

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