Molecular Mechanism of ATP synthesis

Current model based on structural data, largely from the Walker lab, and biochemical data from various labs.

Category:

Film & Animation

Tags:

• ATP
• synthesis

[smokedog77]

it would be nice if there was sound to this video describing what everything is

[CurtisVector]

If this really is depicting the action of ATP synthase, then it's showing the chemical reaction going backwards. I'll explain the reaction taking place first how it is depicted (as if it were the hydrolysis of ATP to form ADP and Pi, moving forward in time), and then I'll explain the reverse reaction (as if it were depicting the synthesis of ATP backwards in time, though my explanation will move forwards in time). Since these comments have a character limit, I'll do it in a series of replies.

[q0L0b]

nice animation but adding some narration would be very helpful....thanks.

[TheGrotesqueReality]

Sound Sound......

[JTS11d6]

This is the shit, to think that this is the source of energy for all biological reactions.

[wolfgangouille]

@BlackyJerome It is Mg2+

[DreamsofMajesty]

scribd (dot) com/nb812

[BlackyJerome]

Very nice and demonstrative!! but this is ATP-synthetis backward right? and I couldn't identify the neon green atom, what is it?Thanks^^

[TheFluorineMartyr]

Isn't that beautiful?

[CookieMcWeaksauce]

Hehe, yeah. I was realllly confused until I realized a Pi group was leaving - the reaction is runnign backwards. Misleading video title is...misleading.

[CurtisVector]

The second half of the animation is showing the same thing from a different perspective.

If you were to visualize this reaction in reverse, the beta phosphate of ADP would become the nucleophile (via an oxygen atom) and the water molecule would become the leaving group of the Sn2 reaction.

Sorry if that was unclear. I'm not trying to show off by using chemistry/biochemistry jargon, just trying to be as unambiguous as possible.

[CurtisVector]

The conformation continues to change as the reaction progresses. The incoming white ball is the nucleophilic water molecule in an Sn2 reaction with the gamma phosphate. It can be seen hydrogen bonded to serine, glutamic acid, and arginine residues. After the reaction occurs, the substrates leave the active site, and the conformation returns to its native state. I forgot to mention earlier that you can see phenylalanine and tyrosine residues forming Van der Waals interactions with adenine.