TSB's Christian Okoye versus the Indianapolis Colts defense. One run, one quarter of play, 75 yards, and around 60 broken tackles.
When Okoye is in "Good" or "Excellent" condition, the Colts defense is incapable of tackling him without diving. If they simply run into Okoye, they'll bounce right off of him. This is because Okoye is the strongest runner in the game, and the Colts defenders tend to be very weak hitters.
Like Bo Jackson, Okoye had a stellar NFL career that was prematurely ended by an injury.
On a different note, congratulations to the real-life Colts for winning Super Bowl XLI.