Mechanism of Anthrax Toxins

Anthrax is an acute infectious disease caused by the spore-forming gram positive, aerobic bacterium Bacillus anthracis, whose pathogenesis is primarily the result of a tripartite toxin. This toxin is composed of three proteins: the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). These proteins work together to enter a cell and disrupt the signaling pathways. Secreted from the bacteria as nontoxic monomers, these proteins assemble on the surface of Anthrax Toxin Receptor (ATR)-bearing eukaryotic cells to form toxic noncovalent complexes. The process starts when the 83 kDa PA (PA83) monomers bind to the ATR Receptor. Once bound, a 20 kDa N-terminal fragment (PA20) is cleaved off of PA83,leaving behind the remaining 63 kDa portion (PA63). PA63 rapidly oligomerizes to form a heptamer pre-pore,which then associates with up to three molecules of EF and/or LF. The cell then endocytoses the complex and carries it to an acidic compartment, where the low pH causes a conformational change in the PA63 pre-pore that forms a cation-specific channel and allows the EF and LF to enter into the cytosol. Once in the cytosol, the EF and LF then carry out their respective damage-inducing processes, ultimately causing Apoptosis. Anthrax is a disease that has plagued man and his livestock for centuries, causing it to be one of the most well-studied and understood diseases. This animation provides an overview of the mechanism of Anthrax toxin in case of pulmonary infection, the most fatal form of infection causing Anthrax.

Category:

Science & Technology

Tags:

• Mechanism of Anthrax Toxins
• custom animation
• biology animation
• custom biological animation
• biological animation
• Anthrax
• bacillus anthracis
• b. anthracis

[natemorey]

its always cool to see things like this, our bodies and everything infecting them are like little machines.

[a55kika18]

Dude!

This is the most organized shit ive ever seen in my whole life

[julqw2]

@Sir0ishi thru cuts on skin when handling contaminated material

[rubigt]

gracias!!!

[Sir0ishi]

how does anthrax infect through cutaneous infection??

[SuperJenitza]

yes, it is super sensacionality, amezing job.. CONGRATULATIONS AND THANKS ITS VERY HELPFULL

[monusac]

It is really awesome.

[BytaryHeart91]

Great video thanks

[58116111]

THE VIDEO IS WONDERFUL, congratulations, THE VIDEO IS AWESOME