Cancer Immunotherapy Breakthrough : Dr. Cassian Yee - Fred Hutchinson Cancer Research Center

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Uploaded by on Jan 14, 2012

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(Immunotherapy Research)

Dr. Cassian Yee, Drs. Zihai Li and Bei Liu,, Zheng Cui, Ph.D, William Coley, Victor Ambros, Gary Ruvkun, and David Baulcombe, Gary Davis

http://youtu.be/IABL-kpQBwA

http://youtu.be/zt5D3-xD2es

The Fred Hutchinson Cancer Research Center is a world renowned research facility.

The doctors and scientists at the Center have help shepherd in life saving changes to patients with leukemia, different types of cancers and HIV/AIDS.

One of their latest discoveries here to treat cancer, doesn't come from outside drugs, but rather, from within the patient.

Immunotherapy is the process of boosting the body's own immune system to fight deadly disease.

Seattle Channel's Roxeanne Vainuku has more on how Dr. Cassian Yee is helping to lead the way in this field of study. http://www.seattlechannel.org/CityStream/

http://youtu.be/ct6nNYHtW80

http://youtu.be/t3bI9nBa4FY

Research @ http://www.youtube.com/sn1pe352

http://youtu.be/J4-6h5CkX2k

UConn Health Center researchers have uncovered a way to potentially use human stem cells as a kind of vaccine against colon cancer.

This discovery, led by experts in immunology, Drs. Zihai Li and Bei Liu, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumor response by "fooling" the immune system into believing that cancer cells are present.

The finding potentially opens up a new paradigm for cancer vaccine research.

http://youtu.be/MMhSaT6fS18

http://youtu.be/MboRT7MUNiU

http://youtu.be/SJUbqAsmuQ0

http://youtu.be/oB9Ud31UX-g

http://youtu.be/35Nj_t5nd2o

http://youtu.be/olvwglPEGi8

http://youtu.be/gjwLyoGDV8U

"By using a probe to shine a light on the tumour, the antibodies at the right place in the body can be brought to life.

Any antibodies in the rest of the body will remain dormant, meaning side effects can be minimised.

The activated antibodies then cause immune cells in the blood called T-cells to attack the cancer."

"Just a few minutes of the light therapy directed at the region of the tumour would activate the T-cells causing her body's own immune cells to attack the tumour."

http://youtu.be/da9z30QsE9k

November 13, 2007 presentation by Edgar Engleman for the Stanford School of Medicine Medcast lecture series.

Edgar Engleman, MD, medical director of the Stanford Blood Center, discusses his research involving the use of a special type of white blood cell as a treatment for cancer. Engleman, who is also a professor of pathology at the Stanford School of Medicine, and his team of researchers have been interested in dendritic cells, or DCs, which can provoke an immune response in the body.

Stanford University School of Medicine:
http://med.stanford.edu/

Stanford University Channel on YouTube:
http://www.youtube.com/stanforduniversity

Immune cells in some cancer patient recognize, attack, and kill cancer cells, leading to full patient recovery.

Recently Steven Rosenberg at the National Cancer Institute isolated these cancer kiling T cells (tumor-infiltrating lymphocytes) in a patient who had successfully beaten melanoma.

He then introduced genetic information from them via a harmless retrovirus into the T cells of patients suffering from active cases of potentially deadly melanoma.

Coley's first intentional erysipelas infection was performed on a patient named Mr. Zola on May 3, 1891, who had tonsil and throat cancer. Mr. Zola came down with erysipelas and his condition improved tremendously. Mr. Zola lived for another eight and a half years.

Coley was convinced that he could effectively use bacteria to treat cancer and created a mixture of killed bacterial infusions since known as Coley's Toxins or Coley's vaccine.

The infusion was administered by injection in increasing doses to induce a fever.

Once stimulated, he observed, the immune system could be capable of tackling cancerous cells along with the infection

Coley developed the theory that it was the infections which had helped patients in the past to recover from their cancer.

So he began to treat patients by injecting a brew of Streptococcus pyogenes directly into inoperable tumors.

This met with much success, even after metastasis.[citation needed]

The treatment was most effective when it provoked a fever and a full-blown infection.

This observations coincided with similar observations in 1867 by the German physician W. Busch when his patient's tumor became smaller after a high fever.

Later, Coley decided to use a mixture of dead Streptococcus pyogenes and dead Serratia marcescens bacteria.

According to Stephen Hoption Cann of the University of British Columbia, "He had successes you simply couldn't hope for today, curing even extensive metastatic disease."

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Uploader Comments (sn1pe352)

  • Coley developed the theory that it was the infections which had helped patients in the past to recover from their cancer.

    So he began to treat patients by injecting a brew of Streptococcus pyogenes directly into inoperable tumors.

    The treatment was most effective when it provoked a fever and a full-blown infection.

    According to Stephen Hoption Cann of the University of British Columbia, "He had successes you simply couldn't hope for today, curing even extensive metastatic disease."

  • (RobertsReview, RI, USA) -- Immune cells in some cancer patient recognize, attack, and kill cancer cells, leading to full patient recovery.

    Recently Steven Rosenberg at the National Cancer Institute isolated these cancer kiling T cells (tumor-infiltrating lymphocytes) in a patient who had successfully beaten melanoma.

    He then introduced genetic information from them via a harmless retrovirus into the T cells of patients suffering from active cases of potentially deadly melanoma.

  • "By using a probe to shine a light on the tumour, the antibodies at the right place in the body can be brought to life.

    Any antibodies in the rest of the body will remain dormant, meaning side effects can be minimised.

    The activated antibodies then cause immune cells in the blood called T-cells to attack the cancer."

    "Just a few minutes of the light therapy directed at the region of the tumour would activate the T-cells causing her body's own immune cells to attack the tumour."

  • The Fred Hutchinson Cancer Research Center is a world renowned research facility.

    The doctors and scientists at the Center have help shepherd in life saving changes to patients with leukemia, different types of cancers and HIV/AIDS.

    One of their latest discoveries here to treat cancer, doesn't come from outside drugs, but rather, from within the patient.

    Immunotherapy is the process of boosting the body's own immune system to fight deadly disease.

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All Comments (5)

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