How Immunology Saves a Life

How the adaptive and innate immune system saves your life...and gives you a parking fine. Parody of "How to Save a Life" by The Fray

Project by Stephanie Hsi and Sidd Krishnamurthy

Video:
Red shirts - Pathogen
White shirt - Macrophage (Usually)
Black Shirt - T-Cell

Lyrics
Step one, you step on a sharp rock
You say oh well, it left such a small mark
But just that little bit of rust
Resulted in acquiring Tetanus

Onset of this of this infection
caused macrophage activation
NF-kB made IL 1, 6, TNFa
you begin to wonder why fever came.

What a poor defense, I'm feeling sick
Redness, swelling and tenderness
And I would have cleared it by now, abated
Had I been vaccinated

DC TLR 5 liked flagellin
And TLR 4 was LPS stalkin'
Try to slip past its defense
But antigens aren't innocent

Travel down the lymph nodes in a throng
B seven signals growing strong

And pray that T cells miss you
Yeahhhh, pray that T cells miss you


Why's this bond so strong, CD28
Costimulated and I just can't wait
To proliferate, differentiate
T-cells know how to save a life

As CD8 T-cells leave this place
It's finally time to make just one last choice
TH1 with IFN
Or TH2, IL-4 secretion?

He will do one of two things
He will support the macrophage
Or he'll play the B cell's game
CD40L will express all the same

B cells secrete IgM and D
recognizes the pathogen
AID help to class switch to IgG
Somatic Hypermutation
Complex forms between Ab-Ag
Complement flows surreptitiously
Punctures the membrane with all of its might
And attracts lots of phagocytes

I fell on to a knife
Let's do this one more time

Secondary response, I've got a friend
Plasma, antibodies, and memories
Soon I will clear this disease
Memory response, I do a dance
Damn pathogens don't stand a chance
And now I will stay up with you all night
Because my final is at 9...

A parking, I'll take the fine
If only I had more time

Category:

Education

Tags:

• medicine
• parody
• immunology
• goldrath
• UCSD
• Stephanie
• Hsi
• Sidd
• Krishnamurthy
• Nerdy
• Biology
• The
• Fray
• How
• to
• Save
• Life

[Antonto89]

"As CD8 T-cells leave this place

It's finally time to make just one last choice

TH1 with IFN

Or TH2, IL-4 secretion? "

it's CD4+ ones that differentiate into Th1 or th2 , not CD8.

Quite nerd, though! :)

[kooziejr]

@losangelesrep Obviously....

[losangelesrep]

@kooziejr in an autoimmunse response, not all the time...

[trombonbe42288]

It just occured to me while watching this video that zombies are really just human phagocytes.

[kooziejr]

hahaha this is fantastic....funny thing is the immune system is actually what causes your death as well haha --> cytokine storm!!!!

[shaaa19]

LMAO u guys must love immunology!!

[Rubynery]

I hope you got an A+ for this :)

[honglou168]

literally LMAO

[Sporkk1]

I laughed at "-10 HP!" when the IgM hit the pathogen guy.

[tuddyfruity4]

this was very very good- thanks for the study help