YouTube home Comedy Week on YouTube
Upload

HIV Replication 3D Medical Animation

Rufus Rajadurai Rufus Rajadurai·29 videos
1,992
1,235,329
Like     Dislike 91

Sign in to YouTube

Sign in with your Google Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to like Rufus Rajadurai's video.

Sign in to YouTube

Sign in with your Google Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to dislike Rufus Rajadurai's video.

Sign in to YouTube

Sign in with your Google Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to add Rufus Rajadurai's video to your playlist.

Uploaded on Mar 3, 2007

It is a very excellent animation which explains the hiv replication very clearly.
For free download of this video please visit my webpage
http://3dmed.wetpaint.com/
And other 3D animation videos visit
http://3dmed.wetpaint.com/page/3D+Med...
Regards,
Dr.Rufus

The Lyrics of this video is here

Targeting HIV replication

The replication of HIV 1 is a multi-stage process.

Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs.

Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte.

Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4.

These receptors interact with protein-complexes, which are embedded in the viral envelope.

These complexes are composed of two glycoproteins:

an extracellular gp 120 and
a transmembrane gp 41

When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment.

It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120.

This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane.

Gp 41 then folds back on itself.

This draws the virus towards the cell and facilitates the fusion of their membranes.

The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes:

Integrase, Protease and Reverse Transcriptase.

Reverse Transcriptase begins the reverse transcription of viral RNA.

It has two catalytic domains:

The Ribonuclease-H active site

And the polymerase active site

Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA.

The polymerase then completes the remaining DNA-strand to form a DNA -- double helix.

Now Integrase goes into action.

It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends.

Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome.

The host cell genome now contains the genetic information of HIV.

Activation of the cell induces transcription of proviral DNA into messenger RNA.

The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised.

Some of them have to be processed by the viral protease.

Protease cleaves longer proteins into smaller core proteins.

This step is crucial to create an infectious virus.

Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid.

This immature particle leaves the cell acquiring a new envelope of host and viral proteins.

The virus matures and becomes ready to infect other cells.

HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression.

Drugs which interfere with the key steps of viral replication can stop this fatal process.

Entry into the host cell can be blocked by fusion inhibitors for example.

Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens.

The action of Integrase can be blocked.

Protease inhibitors are also part of standard antiretroviral therapy.

Each blocked step in viral replication is a step towards better control of HIV disease.


Script, Storyboard, Art Direction by: Frank Schauder, MD
Animation: MACKEVISION
Publicity: Dr.Rufus Rajadurai.MD.,D.DiaDENS.,

  • Category

  • License

    Standard YouTube License

Loading icon Loading...

Loading icon Loading...

Loading icon Loading...

The interactive transcript could not be loaded.

Loading icon Loading...

Loading icon Loading...

Ratings have been disabled for this video.
Rating is available when the video has been rented.
This feature is not available right now. Please try again later.

Top Comments

  • Grey Baxen Nicolae

    looks like an alien invasion

    · 7

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Grey Baxen Nicolae's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Grey Baxen Nicolae's comment.
  • Talagabb Tocy

    to many testimonies that silver colloidal works and cause no harm to the body...

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Talagabb Tocy's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Talagabb Tocy's comment.

Video Responses


All Comments (2,212)

Sign in now to post a comment!
  • xamandaxgatewayx

    Brilliant!

    

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate xamandaxgatewayx's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate xamandaxgatewayx's comment.
  • Indresh Indu

    Awesome video! Gave so much information! Thanks!

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Indresh Indu's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Indresh Indu's comment.
  • Yon von der Hok

    HIV is the biggest frauds in the world. The documentary Positively False - Birth of a Heresy demonstrate this. This link muvi. es/w2199/144765 the last documentary released about it.A compilation of 25 years of investigation and footage from a production company with documents supporting the fact. The most complete documentary I have ever watched about this. The link is muvi. es/w2199/144765 to the documentary Positively False - Birth of a Heresy.REMOVE THE BLANK SPACE IN THE URL

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Yon von der Hok's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Yon von der Hok's comment.
  • wilyoustay

    narrow transplant of someone with d32 mutation and cures hiv simple... but they say the operation is dangerous so they dont do it:) ye like if the guy who has hiv cares about 10% chance of fail

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate wilyoustay's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate wilyoustay's comment.
  • cheyech kitalei

    The video has given me alot of insight about HIV

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate cheyech kitalei's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate cheyech kitalei's comment.
  • dennis denny

    The animation was so informative of what actually goes on on a micro level.

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate dennis denny's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate dennis denny's comment.
  • MJCJMone

    Oh god I don't want hiv

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate MJCJMone's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate MJCJMone's comment.
  • adogandi

    HIV is a nasty disease and leads many to suicide rather than deal with the disease's side affects. 

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate adogandi's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate adogandi's comment.
  • Thezshooter

    Thank you very much usefull

    ·

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Thezshooter's comment.

    Sign in to YouTube

    Sign in with your YouTube Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to rate Thezshooter's comment.
  • Loading comment...
Loading...
Loading...
Working...
Sign in to add this to Watch Later