Cool Sensory Neuron

In the in vitro skin-nerve preparation you can observe primary sensory neurons and listen to what they say to the brain when they feel temperature or other sensory experiences, such as touch or pain. In response to stimulation they send action potentials to the brain. From this information the brain then integrates the sensory world we are living in... this neuron responds to cold: see how it starts firing as temperature falls, how it adapts and then silences as soon as temperature rises again...

Category:

Science & Technology

Tags:

• Primary
• Sensory
• Neuron
• C-fiber
• action
• potentials

[monkeytap]

it looks like it stops firing BEFORE the temperature rises....is that what you mean by adapt? so the adaption is intrinsic to the cell? interesting....

[drskinnerve]

That's right, adaptation is a key feature of sensory neurons. It also occurs for example in neurons that respond to mechanostimulation or heat stimulation. Basically it means that the cells respond most briskly to fast changes of the stimulus temperature or the stimulus force (in case of mechanostimulation). As soon as the stimulus stays constant the cells reduce their firing rate. Some adapt to zero, others may still keep firing at a low rate.

[Axon36]

Nice video.......however I have a couple of questions because it looks like a cold nociceptor to me. This skin-nerve prep is from a rodent?. The CV it was in the C range?. This cells show any mechanical sensivility?. At which temperature your superfusion bath it was (I can't tell looking your termistor trace). Nice work.

[drskinnerve]

You are right the recording is from a mechanosensitive C-fibre (cold nociceptor). My bath temperature is usually 30°C or just a little bit below.

[schneckenturm]

as I said before: not a single idea - but let me say "nice work" ( haha - my statement is the pure plagiate . But the video is indeed very impressive for me as a alien from the planet of music. I saw the video with Pete Townshend - that´s my world. But on the other side the sound of the equipment was a sort of complicated rhythm! Interesting!

LG from FEU

[monkeytap]

and let me guess.....this is regulated by a (complex) g-protein pathway?!?

I guess I have never really looked at sensory neurons, and thought this process would be spinally mediated, probably both.

I have done some single unit neuron recordings (nucleus accumbens) in vivo rats, fun stuff!!!