Pain Gating Theory

Melzack and Wall retracted their original Pain Gating premise as it was discovered that no "Transmission Cell" or "T" cell exists in the dorsal horn. As the current literature states, nociceptive inhibition that occurs with increased mechanoreceptor activity is a reproducible event. This video explains the current theoretical mechanism.

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Education

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• DC

[DrLeoCharm]

pre-synaptic inhibition would indicate inhibition of the primary afferent nociceptor? a sort of axo-axonic inhibition. ...??

[NeuroDocUniverse]

@DrLeoCharm Though the exact mechanisms of all the incidences of presynaptic inhibition are not fully understood, the basic understanding is the presynaptic inhibition occurs at the receptors of the postsynaptic neuron. I hope this is helpful!

[NeuroDocUniverse]

Thanks for the kind words!

[PalmyBruce]

Helpful thank you - I broke my leg 12 Aug and am exploring pain evasion methods that don't require drugs. I will focus on more use of mechanical activity such as the physio exercises given to me, and general activity. If you have more specific recommendations, please let me know. Bruce Thomson in New Zealand.

[NeuroDocUniverse]

@PalmyBruce

So sorry to hear about your leg, Bruce. Bone pain can take time to heal, so don't give up as it will get better. As I have not examined you or read your radiographs, I cannot give you personalized advice. Generally, movement does help in the perception of pain from many perspectives, but you must be sure to work with your physical therapist on individual limitations so that you do not inadvertently create more pain or slow your healing time. Best to you for a swift recovery!

[gospelfreak77]

Really nice. refreshed College memories and the topic itself !! :)

[elliot0]

Thank you! You have just cleared up something that has been baffling me for the past week!!!

[MrTonypurnell]

Excellent and well paced explanation thank you so much