In this malaria study, TNF-alpha levels were found to be significantly elevated in the cerebrospinal fluid of children with cerebral malaria, in comparison with controls. Copyright 2010 INR®, all rights reserved.
The authors discussed the need for a selective, CNS-active, anti-TNF treatment modality.
Excess TNF-alpha has also been documented in traumatic brain injury, spinal cord injury, neuropathic pain, frontotemporal dementia, sleep apnea, stroke and Alzheimers disease.
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