Lifeforce was the first film of Tobe Hooper's three-picture deal with Cannon. The other two films are the remake of Invaders from Mars and The Texas Chainsaw Massacre 2.
The film marked the fourth project to feature special effects produced by Academy Award winner John Dykstra, the umbrella-like alien spaceship was modelled after an artichoke, while the model London destroyed in the film was actually the remains of Tucktonia, a model village near Christchurch, UK that had closed not long before the shooting of the film. It took a week to film the death scene of the pathologist played by Jerome Willis, and bodycasts of Frank Finlay, Patrick Stewart and Aubrey Morris were made for their death scenes.
James Horner was first asked to write the film score before Henry Mancini was brought in and composed a sometimes atonal score. For the US domestic cut version, Michael Kamen was approved to write the occasional alternative music cues that were partially re-scored and placed in at the last minute for some of the US domestic prints of the film.
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