Hyperbaric-Oxygen Therapy (HBOT) has been used to treat encephalic lesions for over a decade

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"Encephalitis can compromise blood supply to vital brain tissue, as can stroke, arterial narrowing, and arteritis (inflammation of the arteries). When blood supply of an area is compromised, a shadow like spread (called a penumbral zone) of damage occurs around the compromised area. HBOT can reduce damage to the areas of the brain that have reduced oxygen flow (ischemia) through improved bio-availability of oxygen in these ischemic areas, and indirectly through regulatory action of cerebral flow that improves perfusion in ""critical"" areas.

HBOT improves oxygen diffusibility throughout the brain, lowering lactates and raising ATP in affected areas; improving glucose metabolism by lowering production of substances, like aspartate and glutamate, which are responsible for over-response of the receptors; improving metabolic processes and perfusional flow distribution, bringing the generation of free radicals in the intracranial area under greater control.

As therapy can act only on areas not irreversibly damaged, treatment must occur as early as possible.

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