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(3/3) The light of evolution: What would be lost

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Uploaded by on Jan 6, 2010

What good is evolution? Do we really need it? Are there any applications for it? Does it have any bearing on human health? Why would a doctor or engineer or teacher or politician need to understand it, beyond the need to satisfy an educational directive? Does it really affect our lives?


Useful or interesting links:

Understanding Evolution (basic material)
http://evolution.berkeley.edu/evolibrary/home.php

Yale Peabody Museum of Natural History (fantastic videos)
http://www.peabody.yale.edu/exhibits/treeoflife/index.html

"Nothing Makes Sense Except in the Light of Evolution" by Theodosius Dobzhansky, 1973
http://people.delphiforums.com/lordorman/light.htm

Francisco Ayala debate with William Lane Craig
http://www.youtube.com/watch?v=8IY1JffZyRw



Journal articles for further reading:

Free full-text article on XMRV's role in prostate tumor
http://www.pnas.org/content/106/38/16351.full.pdf

Free full-text "Genomics meets HIV-1" on HIV vaccine targets enabled by genomic research
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043131/pdf/nihms29212.pdf

How HIV-1 research is being used to treat FIV in cats
http://www.retrovirology.com/content/pdf/1742-4690-4-79.pdf

Selective Sweeps in the Human Genome: A Starting Point for Identifying Genetic Differences Between Modern Humans and Chimpanzees
http://mbe.oxfordjournals.org/cgi/reprint/19/12/2342

Quantitative Trait Loci mapping of crops
http://www.plantcell.org/cgi/reprint/12/12/2473

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Uploader Comments (C0nc0rdance)

  • What is XMRV? I thought it was a virus that we got from our environment. Are you saying that ERVs become reactivated and produce the XMRV? If not, what is the relationship between the two?

    ERVs insert several genes into our ancestor's genome. These genes get turned off and pass to offspring. I thought that we caught the XMRV from the environment and that it then reactivates some of the genes from the ERV.

    Please help, I am confused.

  • You are no more confused than the rest of us. There's still a great deal of discussion and research on how we came up with a xenotropic mouse retrovirus.

    The most plausible explanation is the "cousins, twice removed" scenario. A mouse leukemia virus exists or existed that was able to infect humans sometime in the distant past. It also infected mice and became a mERV.

    Whether XMRV will be found to be transmissible is a big question. We know it infects human cells in vitro.

  • As I understand it a retrovirus inserts multiple genes into the host genome. These genes code for the proteins to make more copies of the virus. If the genes get turned off and, via gametes, passed to offspring you have an ERV.

    I would think that an ancient ERV, which has been turned off for a million years, would have lots of mutations (no selection pressure to remove them).

    How could an ancient ERV become re-activated and make good copies of the original virus? Is this what is going on?

  • We don't know the answers to that question yet. It is much more likely that XMRV is a cousin to the Moloney Murine Luekemia virus (MMLV), and that the endogenous retrovirus represents a sort of Last Common Ancestor (LCA) virus between MMLV and XMRV that left its fossils (ERV) in the genome of mice.

    These are good questions, and watch this space, but we don't know the answers yet. I suspect XMRV is a low-transmissible virus, but it DOES form virion particles found in tissues.

  • Mm. I saw these videos were up, sat myself down with a lovely cup of tea, and thoroughly enjoyed this superb mini-series!

  • Deeply appreciated, Theramin, I really enjoy your videos as well. Some are like an electric shock (in a good way).

Top Comments

  • Damn I thought all this information was in the first chapter of the bible.

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  • Nicely done!! . . .

  • Thank you very much for this awesome series. I have a question to the screening method you present @5:00: The method will most likely not find a substance where the effect would be based on the interdependency of some of the parts.

    Do such interdependencies not occur on this level, or is the method mostly ignoring this possibility because it is simply the best available method?

  • I think monogamy is CULTURAL not biological in humans.

    Not everything in humans in biological the more nonsensical it is, the more likely it's a product of culture far more then genetics.

  • don't listen to people online because they will say oh god this and that but they don't know shit and most of them are trolls and shills.

  • I think you messed up on the quote at the end of this video...

    "we will not be able to close this gap if we substitute ideology for fact"

    We should substitute ideology for fact... wtf, why not... facts and evidence are better than religion and ideology... so I think you might have messed up the quote...

    Good video though :)

  • You would 0-star this series because you're religiously biased? That sadly says much more about you than it does about evolutionary biology and beyond. Sad.

  • I like what you said about this being between Science and Anti-Science, not evolution and religion.

    My father has a PHD in Nuclear Physics but is a devout Catholic and believes in divinely guided evolution. I find it very sad that evolution has been painted by anti-scientists as an atheist "belief".

    I personally don't see any evidence for divine guidance but I respect his belief. I DO NOT respect the beliefs of anti-scientists.

  • @theDracoIX Why? He's honestly trying to educate people but you're so detemined and set against that - it's disturbing.

  • well put!!!!!!!!!!!!!

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