Complement 3 - Classical and MBL Pathways

http://www.handwrittentutorials.com - This tutorial looks at the Classical and MBL pathways of the Compliment cascade. It follows the tutorial 'Complement 2 - Alternative Pathway'. For more entirely FREE tutorials and accompanying PDFs visit http://www.handwrittentutorials.com

Category:

Science & Technology

Tags:

• Complement
• Classical
• and
• MBL
• Pathways
• Compliment
• Alternative
• pathway
• immunology
• tutorial
• handwritten
• immune
• system
• innate
• medicine
• health
• doctor
• student

[slimels]

I don't get why you're teach pathways in reverse... Very good otherwise.. But why start in the middle, move forward, then go backwards?

[harpinmartin]

@slimels It's not really backwards, the whole cascade revolves around the C3 conversion, so it makes sense to start there. The choice to teach the pathway in reverse was made because it seemed more important to see how the pathway interacted with C3 conversion, but to guard against any confusion an the overview video was created to see how the pathways began, then these videos fill in the details.

[bigstreifel13]

FYI:

C3 convertase = C4b2b (NOT C4b2a)

Or at least that is how I learned it.

Other than that these videos are awesome and very helpful. Thank you

[harpinmartin]

@bigstreifel13 Wikipedia says it best "C3 convertase is, in classical terms, C4b2a; in the 1990s there was a motion put forward to change the nomenclature to C4b2b, however this was unsuccessful."

It just depends how you learnt it, the names are all arbitrary anyway.

[mals0610]

Appreciate the tutorial and the effort...good job.

C3 convertase is C4b2a and not C4b2b...in the case of C2 cleavage products, the nomenclature is different, the larger fragment is called C2a.

However, there is one small thing overlooked in the tutorial. In the classical pathway, the antibodies bind the pathogen using their antigen binding region. In the tute it shows that the binding is using the Fc region. Also, the C1 binding with antibody is using the fc region of antibody.

[Teimengu]

couldn't be easier

you are my first subscribed channel

[kittyshh]

y dun u train my professor??

[riva2987]

subsribed:)



[POPsPuravida]

Amazing work. Thank you very much.