Hepatic Biotransformation
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9:11
Food Toxicology Biotransformation part 1by JNUFoodQualitySafety1,494 views- 0:44
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Pharmacology Distributionby jacksonmelissa119,196 views
I thought Phase I was mainly to make the molecule more water soluble by introducing a hydroxyl group so the molecule can be conjugated to say Glucose [Glucuronidation] or amino Acid [Glycine/Taurine]
not necessarily Phase 1 = inactivation
tell me if I am wrong
b2008uk 3 years ago
Ethanol Stim of CYP450 is on CYP 2E1, which is inhibited by disulfiram and metabolises Ethanol, Theophylline and Paracetamol!
So you'd only be worried if the patient was on Paracetamol or Theophylline and the patient was consuming alcohol or had alcoholic liver disease for paracetamol!
b2008uk 3 years ago
Ph2 Glucoronate
Sulphate
Taurine
Glycine
thanks man! Forgot Taurine could be conjugated
I thought Diazepam wasn't an inducer but only a substrate!
b2008uk 3 years ago