Yo Dr. Hyde, let's kick it
Splice splice baby (x4)
All right, stop, collaborate and listen
Eukaryotes are back with a brand new invention
Splicesomes grab RNA tightly
Excising introns, daily and nightly
Will it ever stop? Yo, I don't know
Remove the lariat, and then WHOAH!
To the extreme, post-transcriptional modification
With the 5' cap and polyadenylation
Splice splice baby (x4)
Now the splice-party is jumping
With the bass kicked in and snRNP catalysts pumpin
Quick to the branchpoint, to the branchpoint no fakin
All the 5' introns are taken
Bonding with the guys at the branchpoint A
5' to 2', that's the way
Forming a lariat -- a souped-up lasso
The lariat's on a role, it decides to go solo
Like Hyde, until he found his wife
Met on a canoe trip, together for life
If there was a problem, Benzer solved it
rdgB? Hyde knows all about it
Splice splice baby (x4)
Take heed, Hyde's a lecturing poet
Alternative splicing, in case ya didn't know it
A cDNA probe on a Northern Blot
Recognizes two sequences... What do ya got?
mRNAs sharing sequences like it's hot
Splice splice baby
Yo man let's get out of here
Word to Dr. Hyde
Sorry, I like the idea, but I can't really hear what you guys are saying
deltaroo420 3 years ago
The lyrics are on the right
FidyYuan 3 years ago