Signal Transduction

This animation describes how growth factors bind to a membrane-bound receptor and triggers a cascade of downstream transduction processes.

Cell behavior is governed by the effects of growth factors which interact with membrane-bound glycoprotein receptors that transduce the first message into a series of intracellular signals that in turn promote or inhibit the transcription expression of specific genes. Cancer cells adopt two principal signaling strategies between cells: endocrine signaling and paracrine signaling. Aside from growth factors, lipophilic hormones such as steroids and thyroid hormone are potent regulators of cell behavior, and may cancers are either hormone-dependent or are responsive to hormone therapy. In the prevention of breast cancer, steroid hormone analogs such as tamoxifen are used to mimic the action of the natural estrogen, eliciting a much weaker estrogenic response. This animation is general in scope, so it can be used in various different lecture contexts.

Created by:

Steve Huang
Class of 2004
Mechanical Engineering
STA member since 2001

Dr. Bongsup Cho - URI Pharmacy ProfessorDr. Bongsup Cho
Professor of Biomedical and Pharmaceutical Sciences
College of Pharmacy

Category:

Film & Animation

Tags:

• Signal
• Transduction
• Pharmacy
• URI
• animation

[xfactorAD28]

my dick explains signal transduction better than this video ever could.

[Ardwynna]

Garishly done, lacks explanation, takes too long to show any process at all, essentially demonstrates nothing.

[vivekkathula]

audio ???

[oglow100]

huh?!

[DeterminedStarfish]

Random colourful crap moving around in crap motion in a pit of crappy demonstration. Waste of my study time!

[PrettieDebbie]

i kept on waiting to actually hear someone speak!! waste of time!

[stburnet]

Awful



[gykmeister]

Merely looks like a dodgy version of the ghosts in super mario....... needs audio at least and to be faster

[apoorbengbeng]

this really doesnt help

[MyHonestyMightHurt]

agreed, a narrative would do wonders