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Signal Transduction

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Uploaded by on May 1, 2007

This animation describes how growth factors bind to a membrane-bound receptor and triggers a cascade of downstream transduction processes.

Cell behavior is governed by the effects of growth factors which interact with membrane-bound glycoprotein receptors that transduce the first message into a series of intracellular signals that in turn promote or inhibit the transcription expression of specific genes. Cancer cells adopt two principal signaling strategies between cells: endocrine signaling and paracrine signaling. Aside from growth factors, lipophilic hormones such as steroids and thyroid hormone are potent regulators of cell behavior, and may cancers are either hormone-dependent or are responsive to hormone therapy. In the prevention of breast cancer, steroid hormone analogs such as tamoxifen are used to mimic the action of the natural estrogen, eliciting a much weaker estrogenic response. This animation is general in scope, so it can be used in various different lecture contexts.

Created by:

Steve Huang
Class of 2004
Mechanical Engineering
STA member since 2001

Dr. Bongsup Cho - URI Pharmacy ProfessorDr. Bongsup Cho
Professor of Biomedical and Pharmaceutical Sciences
College of Pharmacy

Category:

Film & Animation

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License:

Standard YouTube License

  • likes, 51 dislikes

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Top Comments

  • my dick explains signal transduction better than this video ever could.

  • Garishly done, lacks explanation, takes too long to show any process at all, essentially demonstrates nothing.

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All Comments (13)

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  • audio ???

  • huh?!

  • Random colourful crap moving around in crap motion in a pit of crappy demonstration. Waste of my study time!

  • i kept on waiting to actually hear someone speak!! waste of time!

  • Awful

    

  • Merely looks like a dodgy version of the ghosts in super mario....... needs audio at least and to be faster

  • this really doesnt help

  • agreed, a narrative would do wonders

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