computational modeling for cell trapping microfluidic device

To investigate the dynamics of the cell trapping process, the simulated loading of the individual trapping arrays and sieve conformations was analyzed at discrete time steps. Analysis of the figure reveals that the filling of the traps at the prescribed flow rate and cell concentration 1 micro Litter/min, 5000000 cells/mL occurs quite rapidly. By 30 s, most of the traps are fully occupied, with few cells added between 30 and 90 s.

related article:
1. Building a Better Cell Trap: Applying Lagrangian Modeling to the Design of Microfluidic Devices for Cell Biology, Min-Cheol Kim, Zhanhui Wang, Raymond H. W. Lam and Todd Thorsen, Journal of Applied Physics, 103 (2008) 044701.

2. High-Density Microfluidic Arrays for Cell Cytotoxicity Analysis, Zhanhui Wang, Min-Cheol Kim, Manuel Marquez, and Todd Thorsen, Lab on a chip, 7 (6) (2007) 740-745.

Category:

Science & Technology

Tags:

• computer
• simulation
• microfluidics
• device
• particle
• cell
• dynamics
• biofluid
• CFD
• biomems
• Lagrangian
• microfluidic
• lab
• on
• chip
• type