Jim Wells and Michelle Arkin (UCSF) Part 2: From "Hit" to Pill

The modern drug discovery process integrates our deepest understanding of the molecular basis for disease with fundamental understanding of how potential drug molecules interact with specific disease targets and the whole organism. These two lectures are intended to give a broad and general introduction to the drug discovery process. Part II focuses on the later stages of the drug discovery process. After the identification of the first hit compounds, iterative rounds of chemistry, biochemistry, cell biology, pharmacology, and toxicology are used to progressively build and polish compounds to make them ready for clinical trials. The adventure of drug discovery represents one of the most fascinating and beneficial pursuits in science. See more at http://www.ibioseminars.org

Category:

Science & Technology

Tags:

• drug discovery
• chemical potency
• cellular potency
• toxicity
• drug metabolism
• pharmacokinetics
• lack of efficacy
• small-molecule
• clinical trial

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drug discovery