3 best friends embark on the adventure of a lifetime. FYI - I missed the fact that GP1BReceptor activates the initial platelets when it binds to the vW Factor. Also, GP2b/3a is activated when the platelet becomes active - active GP2b/3a is able to bind fibrinogen in order to act in platelet aggregation. Coagulation Pathway Initiation: Intrinsic (endothelial injury) - trauma, burns, gram-negative sepsis, hypoxia, acidosis, shock, vasculitis... Extrinsic (tissue injury) - trauma, obstetric complications, complications of cancer...
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