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synapse pain modulation

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Uploaded by on Mar 18, 2009

A synapse in the trigeminal subnucleus. Red (afferent presynaptic primary) axon releases glutamate which activates AMPA receptor. AMPA in turn triggers expression of NMDA receptor which causes further expression of more AMPA. This results in more glutamate being released. GABA/glycine appears as a cloud from the blue "Off" interneuron. Increased GABA/glycine blocks glutamate from binding to AMPA and NMDA. Microglia release cytokines when activated. Modeling and base animation created using Newtek's Lightwave

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  • im guessing the red one is the hotwire and the blue the fog of forgetfulness to long term memory, the orange one has got to be the hd. yoosdef

  • Vocal explanation will be very helpful

  • Nice animation, but without vocal explanation it is hard to understand.

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