BIOESSAYS (Wiley-Blackwell): The role of ECSIT in Alzheimer's disease

Alzheimer's disease (AD) includes many different pathological components (such as build-up of amyloid-beta plaques, mitochondrial dysfunction, elevated oxidative stress and inflammation) but it is still not clear how these phenomena are related to each other.

Soler-López M, Badiola N, Zanzoni A, Aloy P (2012), Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction (BioEssays, 34, doi: 10.1002/bies.201100193) postulates that the signal transduction mediator ECSIT (evolutionarily conserved signaling intermediate in Toll pathway) might act as a molecular sensor in the pathogenesis of AD.

The model presented here integrates seemingly controversial hypotheses for familial and sporadic forms of AD and envisions ECSIT as a biomarker to guide future therapies to halt or prevent AD.

This is a video with one of the study's authors explaining their hypothesis.

Read the article here: http://onlinelibrary.wiley.com/doi/10...

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