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Robert Lefkowitz (Duke University) Part 2 Beta-arrestins

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Uploaded on Mar 22, 2010

http://www.ibiology.org/ibioseminars/...

In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org

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