The Dose Makes the Poison (1/2)

Chemical toxins are a real health risk. So is radiation. But should we be extrapolating the effects of certain toxins at high doses down to a low-level exposure? Is this a linear non-threshold relationship between exposure and health effects?

When we evaluate the arguments of non-scientists, websites, media figures, and pseudoscience publications, a pattern emerges of extrapolation that is not justified from the evidence. Mercury in flu vaccines are present at a small fraction of the dose that is known to cause deterministic health effects. Squalene is found at higher doses in the human liver than in vaccines. And fluoride is only dangerous when it's at 5-10 times higher levels than are found in drinking water in the western world.

If you are interested in learning more, I suggest you start with the following sites:
http://en.wikipedia.org/wiki/Linear_no-threshold_model
http://en.wikipedia.org/wiki/Radiation_hormesis
"Hormesis: a revolution in toxicology, risk assessment and medicine" EMBO Rep. 2004 October; 5(Suppl 1): S37S40. doi: 10.1038/sj.embor.7400222.
http://www.cdc.gov/vaccinesafety/updates/thimerosal.htm
http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/VaccineSafety/UC...
http://en.wikipedia.org/wiki/Squalene

Category:

Education

Tags:

• vaccine
• toxicology
• LD50
• mercury
• thimerosal
• squalene
• fluoride
• radiation
• Hiroshima
• Minimata
• hormesis
• linear
• non-threshold

[mickeypopa]

I'm interested, if MD50 is a lethal dose for 50% of the population, does that mean that it would take almost double the MD50 dose to kill top 1% (at the end of the scale) of the same population?

In other words, if median lethal dose is administered to all 100% of the population, will 50% die and 50% survive?

And is that population comprised of the individuals that are of same age, gender and health?

Also, wouldn't the dose, at which even 1 average healthy person dies, be considered lethal?

[C0nc0rdance]

@mickeypopa

The article on the topic on Wikipedia is a good summation. LD50 is more or less an arbitrary, relative measure of acute toxicity.

LD1 and LD99 are measurable points, but there may not be a --linear-- relationship. There may be 100 points from LD1 to LD50, but only 5 points from LD50 to LD99. A curve is usually created with an endpoint like lethality on one axis, and dose on the other. This is the dose-lethality curve.

The populations are usually isogenic animals (clones).

[C0nc0rdance]

@mickeypopa

The general assumption of statistical sampling is that you have a normally distributed group in the test, so that we can extrapolate from that group to the whole population. The LD50 would (hopefully) represent a median point where 50% of all the animal model would die.

It's use is not in absolutely determining what is safe to use, but in ranking the acute toxicity of exposures. It is not the best measure of toxicity, but nevertheless very useful and historically supported.

[Didyouknowthisstuff]

For me its not the mercury, it is the lack of studies for side effects. Period.

[C0nc0rdance]

Flu vaccines have been used for over 70 years, given to millions of people in multiple countries every year; the elderly, children, and those with chronic diseases included.

What kind of side effects did you have in mind? Something that has never been tested for?

[LBiolSci]

Actually to understand why they can not declare that no harm will be done by water fluoridation, first you need to understand scientific method. Scientific method is hypothetico-deductive. It does not prove anything, however it disproves the opposing ideas. When it can not disprove a opposing idea it accepts is as objectively true and waits to see if it can disprove it later with the help of future evidence. Absence of evidence is not an evidence of absence.

[RexFordVII]

I completely believe you when you say your an info junkie. Now you have to take the next step and set up objective parameters to determine which info is credible and which is not.

If you believe fluoridated water is some how harmful at municipal concentrations, you're subscribing to bad information.

Sit down and really think right now what your standards are for accepting a claim.

[LendMeYourHand]

Have some spelling errors. You mark my words. They will introduce Fluoride power plants & still no one will ask why. Instead, they will be told what to think. This will be there solution to Uranium alternatives while no one will draw the relation. Years from now you will find i was right. Infact, you will then realize that fluoride,uranium,radon,hydroca­rbons are forming pockets under tectonics that are being caused by offshore oil drilling.  Increasing Earthquakes & Volcanoes. coming soon.

[LendMeYourHand]

Hydrogen peroxide in the ears. When your eye ball feels a cold flush, your done. do in both ears daily starting with the right ear. Food grade HP in distilled water. 1 drop food grade iodine under the tongue. sodium bicarbonate(3 tsp daily), Potassium has gamma which vibrates higher than alpha waves is natural brain food. I am not positive, but in low doses can negate free radicals or transport them(cant remember), but dont qoute me. AND!!!!!! Canabinoids = tree of life. Oxydize blood.

[LendMeYourHand]

@sarcleaeolist Its the electronegative ionic bond on 1 single shared electron which creates the instability, thus verification of decay rate. As this cannot be compared to alpha particles when in relation to external contamination, which is why 3mile Isle reports the profound contamination through ingestation of fluoride. It is the Ide which initiates the instability off ionic bonding that clearly tells us a tale of Ultra Violet emmisions. Volcanic rocks & villiaumite. F18's halflife is low.

[sarcleaeolist]

@LendMeYourHand I will make no claim to be a physicist, but no types of radiation I am aware of are called Fluoride. The type of radiation with the most mass that I know of is alpha radiation, which is the emission an alpha particle consisting of two protons and two neutrons. This is a far cry from the anion of Florine with its nine protons, eight electrons, and roughly ten neutrons (I say roughly due to isotopes which may contain more or less in the neutron department, such as F-18).

[LendMeYourHand]

I dont know the exact science, but mercury in sertain animals have some compound that allows it to digest, you are more likely to get Hepatitus before you get mercury poisoning from what i think was fatty fish. So its actually ok to eat some types without any ill effects. Wish i could find that info. Also, Fluoride is radiation. It can be found in Villiaumite, a rock that fluoresces under UV light & has a MOH's hardness. You guys are the science pro's right? isnt that a state of decay?isotope

[dookiecheez]

Sometimes I wish I could make certain youtube videos part of the mandatory curriculum in schools.

[wheelori814]

you should research squalene (found in fish oil, especially skate liver oil and shark liver oil) taken ORALLY!!!! squalene given in injection is extremely bad, but taken orally is fantastic and has manyyyyyy benifits including getting rid of toxins in the body and makes more white blood cells which helps with radiation...

[TooMuchToo0ften]

This puts the cell phone danger to bed nicely

[vesman81]

You should do a video on the LD50 of Cannabis and compare that to its current legal status.

[TheCaptainLulz]

From what Ive read so far, the hormetic model seems to most accurately represent the effects of radiation. Research data seems to hypothesize that very low doses do infact trigger repair mechanisms. We'll probably have to wait for further research to take this to a theory but its interesting none the less.