How Medicines Work: Drug Problems 3: Interactions and Substrates

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In this lecture, Professor Roller reviews the action of enzymes on drug metabolism, singling out Cytochrome P450 and particularly P34A. He defines the two types of drug interaction--drug inhibition and induction—and explains their impact on a drug's effectiveness. Substrates are reviewed. The effect that inhibitors and inducers can have on substrates is discussed, particularly in relationship to a medicine's effectiveness or toxicity. He demonstrates how food, smoking and genetic factors can inhibit or induce the metabolism of medicine by reacting with the substrate.

== Learning objectives ==
The objectives of this session are to:
- Learn the harmful and beneficial side effects of drug interaction.
- Know the factors that can affect how a person metabolises medicines.
- Review the steps to take to anticipate or alleviate the effects of a drug interaction.

== About the Presenter ==
Honorary Associate Professor Louis Roller joined the Victorian College of Pharmacy (now named; The Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia) in 1963. He was variously the Associate Dean Teaching (1992-2006) of the Faculty and Head of the Department of Pharmacy Practice (1992-2001) and Director of the Pharmacy Program until his retirement in December 2008. He has served on the Pharmacy Board of Victoria for 22 years and has contributed to various editions of the Australian Pharmaceutical Formulary Handbook and the Therapeutic Guidelines Antibiotic and Oral & Dental.

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